Exploring Nanohydroxyapatite: Benefits for Dental Care

Exploring Nanohydroxyapatite: Benefits for Dental Care

Have you ever wondered if there’s an alternative to fluoride for maintaining strong, healthy teeth? Enter nano-hydroxyapatite (nano-HA), a revolutionary dental care ingredient that is gaining popularity worldwide for its promising benefits. In this blog post, we’ll explore the science behind nanohydroxyapatite, its various applications in dentistry, and how it compares to fluoride in terms of effectiveness and safety.

Key Takeaways

  • Nanohydroxyapatite is a synthetic mineral with superior properties for addressing dental issues and promoting dental health.
  • It has multiple applications, including enamel remineralization, implants and bone grafts, and restorative materials.
  • Potential health risks associated with the use of nanohydroxyapatite should be carefully considered before use.

The Science Behind Nanohydroxyapatite

Nano-hydroxyapatite is the synthetic counterpart of hydroxyapatite, a naturally occurring mineral found in tooth enamel and bones. It was first developed by NASA in 1970 to replace the mineral loss from astronauts’ teeth and bones, including the enamel surface, due to prolonged stays in a zero-gravity environment. Interestingly, nano hydroxyapatite particles account for 60-70% of bone and 90% of tooth surface (enamel) in weight.

Nanohydroxyapatite possesses remarkable mechanical, physical, and chemical properties, such as heightened solubility, elevated surface energy, and enhanced biocompatibility. This makes it effective in addressing initial enamel lesions and improving overall dental health. Nanohydroxyapatite is a rich source of free calcium, vital for remineralization, protection against dental caries, and dental erosion.

Natural vs Synthetic Hydroxyapatite

Natural hydroxyapatite is a mineral present in nature, while synthetic hydroxyapatite is a manufactured material that can be used as an alternative to fluoride oral care gels. It can be synthesized using various techniques, such as:

  • Co-precipitation
  • Wet precipitation
  • Hydrothermal
  • Mechanochemical
  • Hydrolysis
  • Solid state
  • Sol-gel

Synthetic hydroxyapatite can be used to reconstruct periodontal bone defects.

Nano-hydroxyapatite toothpaste has a marble-like feeling, which is comparable to the texture of regular toothpaste. The type of nanohydroxyapatite obtained from wet precipitation is non-stoichiometric, whereas that obtained from a solid state method is stoichiometric nHA.

Properties of these different types of nHA have been scrutinized through in vitro studies. The wet precipitation technique has the unique advantage of having water as the sole output.

Synthesis Methods

Various synthesis methods, such as wet precipitation, electrospinning, and microwave hydrothermal methods, have been employed to create nanohydroxyapatite for dental applications. A study was conducted to create a composite scaffold material consisting of Nano-Hydroxyapatite-Modified Collagen (nHAC) and Fibroblast Growth Factor (bFGF). This material was developed for use in periodontal tissue regeneration. This material is a 3D structure that has high density and porosity. It increases the loading of bFGF and provides secure attachment for periodontal ligament cells. This helps in promoting cell growth and attachment.

Nanohydroxyapatite has also been incorporated into dental cements used for crown bonding, significantly improving the quality of the bond. Further research observed nanohydroxyapatite’s ability to induce osteogenic differentiation of Periodontal Ligament Stem Cells (PDLSCs). These findings suggest that nanohydroxyapatite has great potential in dental applications, such as teeth restoration and bone grafting procedures.

The integration of synthesized nano-HA and fluorapatite in Fuji II glass ionomer cement led to significant enhancement in the mechanical properties of the resulting cement, including its bonding strength to dentin. This demonstrates the versatility of nanohydroxyapatite in dental material applications, improving both mechanical strength and bonding capabilities.

Applications in Dentistry

Nanohydroxyapatite has numerous applications in dentistry, such as toothpaste for enamel remineralization, dental implants and bone grafts, and restorative dental materials. It facilitates remineralization of enamel, which may aid in the prevention of tooth decay and cavities.

In dental implants and bone grafts, nanohydroxyapatite can facilitate bone growth and regeneration, thus augmenting the success rate of these procedures.

In restorative dentistry materials, nanohydroxyapatite can augment the robustness and longevity of these materials, thereby enhancing the durability of dental restorations.

Toothpaste and Remineralization

Nanohydroxyapatite is employed in toothpaste formulations, serving the purpose of enamel remineralization and caries prevention. It works by depositing apatite nano-particles in enamel defects, facilitating remineralization and inhibiting demineralization. This protective coating around each layer of enamel thwarts bacteria, leading to fewer cavities and improved overall health.

Additionally, nanohydroxyapatite toothpaste can forestall cavities and diminish tooth sensitivity. For optimal effectiveness, it’s suggested to incorporate nano medical hydroxyapatite into your toothpaste regimen twice daily - morning and evening. Regular use of Nano-HA toothpaste can provide relief from tooth sensitivity for several months. This makes nanohydroxyapatite toothpaste an excellent alternative to traditional fluoride toothpaste for individuals seeking a more natural approach to oral care. Fluoride is also a known neurotoxin.

Dental Implants and Bone Grafts

Nano-hydroxyapatite has remarkable osteoinductive capacity and enhances bone-to-implant integration, making it frequently utilized in dental implantology and bone grafting procedures. Using nanohydroxyapatite as a surface coating for dental implants leads to improved osseointegration and better clinical outcomes. The material can be used as a bone substitute for post-extraction socket preservation. This would make it easier to plan future dental implant placement.

Nanohydroxyapatite is also utilized to assist in the reconstruction of periodontal bone defects, such as filling bone defects after a cystectomy and apicoectomies, and to augment the thickness of atrophic alveolar ridges. Its use in dental implants and bone grafting procedures demonstrates the versatility and effectiveness of nanohydroxyapatite in promoting bone growth and regeneration.

Restorative Dentistry Materials

Dental materials include nano-hydroxyapatite to bolster their mechanical properties and effectiveness. It has been shown to significantly improve the mechanical properties and performance of restorative dentistry materials, such as dental cements used for crown bonding and glass ionomer cements. The incorporation of nanohydroxyapatite in dental materials not only improves their mechanical strength but also enhances their biocompatibility, making them more suitable for various dental applications.

One notable example of nanohydroxyapatite’s use in restorative dentistry is its incorporation in dental composite materials. The addition of nanohydroxyapatite particles to these materials results in improved mechanical properties, better bonding strength, and enhanced biocompatibility. This, in turn, leads to more durable and long-lasting dental restorations, ultimately benefiting both patients and dental professionals alike.

Addressing Tooth Sensitivity with Nanohydroxyapatite

Tooth sensitivity, faced by many individuals, can effectively be alleviated with nanohydroxyapatite. By repairing enamel and dentin surfaces, nanohydroxyapatite can effectively decrease tooth sensitivity.

Next, we delve into how nanohydroxyapatite reduces tooth sensitivity and how it fares against other desensitizing agents.

Mechanism of Action

Nanohydroxyapatite reduces tooth sensitivity by:

  • Filling the gaps in the dentin tubules
  • Improving sensitivity duration and intensity
  • Having a high affinity for demineralized surfaces and binding to them
  • Multiplying and aggregating to form microclusters
  • Creating an even layer of apatite that can effectively overlap prismatic and interprismatic enamel
  • Restoring the altered enamel morphology by preserving the crystallinity of the enamel

This mechanism of action effectively occludes the dentinal tubules, inhibiting the hydrodynamic mechanism and attenuating pain stimulation. By fortifying the enamel and obstructing the pathways of the dentin tubules, nanohydroxyapatite diminishes the transmission of sensitivity signals, providing relief to those suffering from tooth sensitivity.

Comparing with Other Desensitizing Agents

Compared to other desensitizing agents like fluoride, potassium nitrate, and strontium chloride, research demonstrates nanohydroxyapatite’s ability to effectively block dentinal tubules, providing relief from dentin hypersensitivity. It also possesses a certain degree of acid resistance, which further contributes to its effectiveness in alleviating tooth sensitivity.

In conclusion, nanohydroxyapatite compares favorably to other desensitizing agents in terms of effectiveness and safety. Its ability to occlude dentinal tubules, inhibit the hydrodynamic mechanism, and attenuate pain stimulation makes it a viable option for those seeking relief from tooth sensitivity.

Safety and Regulatory Status of Nanohydroxyapatite

Like any dental care product, considering the safety and regulatory status of nanohydroxyapatite is crucial. While some studies suggest that nanohydroxyapatite may have cytotoxic effects, causing damage to cells and potentially leading to adverse health effects, other studies indicate that it is safe and non-toxic.

Next, we examine the ongoing debate on nanohydroxyapatite’s cytotoxicity and its standing in dental care regulations.

Cytotoxicity Debate

The cytotoxicity debate surrounding nanohydroxyapatite pertains to its potential deleterious effects on cells and tissues. Some studies propose that nanohydroxyapatite may have cytotoxic effects, instigating damage to cells and potentially resulting in unfavorable health effects. Nevertheless, other studies indicate that nanohydroxyapatite is harmless and non-toxic.

A study by Komiyama et al. demonstrated that nanohydroxyapatite may encounter resistance when trying to penetrate the oral epithelium due to the presence of stratum corneum, making it unlikely to infiltrate systemic regions through the oral epithelium. This suggests that the potential health risks associated with nanohydroxyapatite may be limited.

Further investigation, including an in vitro study, is required to completely comprehend the cytotoxicity of nanohydroxyapatite and its implications for various applications, including dental care.

FDA Approval and International Regulations

The current regulatory status of nanohydroxyapatite varies globally. Here is the status in different regions.

  • United States: nanohydroxyapatite has not been approved by the FDA
  • Japan: nanohydroxyapatite is recognized as “medical hydroxyapatite” and is classified as an anti-caries agent
  • European Union: nanohydroxyapatite is subject to a ban

Given the fluctuating regulatory status and the prevailing cytotoxicity debate, dental professionals and consumers should carefully weigh the potential risks and benefits of using nanohydroxyapatite in dental care. As more research is conducted, the safety profile and regulatory status of nanohydroxyapatite may evolve, potentially leading to broader acceptance and usage in dental care products.

Nanohydroxyapatite vs Fluoride: Weighing the Pros and Cons

Nanohydroxyapatite and fluoride both have demonstrated effectiveness in preventing tooth decay and promoting oral health. However, each material has its own set of advantages and potential health risks.

Next, we consider nanohydroxyapatite and fluoride, comparing their effectiveness in preventing tooth decay and their potential health risks.

Preventing Tooth Decay

Nanohydroxyapatite is an effective alternative to fluoride for preventing tooth decay. It works by remineralizing enamel lesions and forming a more robust protective layer against cavities. As a filler, nanohydroxyapatite repairs minor holes and indentations on enamel surfaces, serving as an alternative to fluoride for decreasing carious lesions.

Meanwhile, fluoride has long been recognized as the gold standard in dental care for preventing tooth decay. It works by strengthening the enamel surface and making it more resistant to acid attacks from bacteria. The problem, it's also a known neurotoxin.

While both nanohydroxyapatite and fluoride are effective in preventing tooth decay, nanohydroxyapatite offers a more natural and biocompatible option for those seeking an alternative to fluoride.

Potential Health Risks

Potential health risks are associated with both nanohydroxyapatite and fluoride in dental care. Some studies suggest that nanohydroxyapatite may have cytotoxic effects, causing damage to cells and potentially leading to adverse health effects. Conversely, fluoride has been linked to certain health risks, such as dental fluorosis, skeletal fluorosis, and thyroid dysfunction.

Before use, it’s important to prudently consider the potential health risks associated with the use of nano medical hydroxyapatite and fluoride in dental care. By weighing the pros and cons of each material, dental professionals and consumers can make informed decisions about the most appropriate dental care products for their individual needs.


In conclusion, nanohydroxyapatite offers a promising alternative to fluoride for dental care, with numerous applications such as toothpaste for enamel remineralization, dental implants and bone grafts, and restorative dental materials. Its effectiveness in preventing tooth decay and alleviating tooth sensitivity, as well as its natural and biocompatible properties, make it an attractive option for those seeking a more holistic approach to dental care.

As with any dental care product, it is essential to consider the safety and regulatory status of nanohydroxyapatite, as well as its potential health risks. By staying informed and carefully weighing the pros and cons of nanohydroxyapatite and fluoride, dental professionals and consumers can make informed decisions about the best dental care products for their needs and contribute to a brighter, healthier smile.

Frequently Asked Questions

Does nano hydroxyapatite toothpaste really work?

Based on various studies and research, it can be concluded that nano hydroxyapatite toothpaste does work; it binds to plaque and bacteria during brushing, acts as an antimicrobial agent, helps with remineralizing small decay, and prevents dental hypersensitivity.

What are the side effects of nano hydroxyapatite?

Nano hydroxyapatite has been found to cause inflammation and DNA damage in some studies, yet the lack of definitive data means the side effects are still widely debated.

What is Nanohydroxyapatite?

Nano-hydroxyapatite (nHA) is a natural mineral that makes up 60 to 70% of human hard tissues and 90% of tooth enamel. It was created in 1970 by NASA to help restore minerals and repair enamel lost in space.

Can Nanohydroxyapatite Remineralize teeth?

Research has shown that Nanohydroxyapatite (nano-HA) can effectively remineralize teeth, with studies indicating similar efficacy to fluoride.

How does nanohydroxyapatite help reduce tooth sensitivity?

Nanohydroxyapatite helps reduce tooth sensitivity by filling in the gaps of the dentin tubules, improving sensitivity duration and intensity, and repairing enamel and dentin surfaces.

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